期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 144, 期 1, 页码 91-98出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-3806(03)00163-9
关键词
rat; dorsal root ganglion; postnatal differentiation
资金
- NINDS NIH HHS [NS37524] Funding Source: Medline
Using both profile counts and unbiased stereological methods, estimates of neuron number in the lumbar dorsal root ganglia of the rat have been shown to increases approximately 35% during postnatal life [J. Comp. Neurol. 386 (1997) 8-15; J. Comp. Neurol. 449 (2002) 158-165]. The mechanism underlying this addition of neurons was investigated. No evidence of incorporation of (BrdU), a mitotic marker. was found. Similarly, counts of myelinated and unmyelinated axons in the sural nerve were the same in neonates and adults. These results are not consistent with the possibility that neurogenesis accounts for neuron addition. A population of neurons that stains with TuJ1. an antibody against neuronal class III beta tubulin, but not with an antibody against the phosphorylated and non-phosphorylated forms of heavy chain neurofilament protein (NF-H) was found in neonates, but not adults. These less-differentiated (type-L) neurons are not detected by either profile counts or unbiased stereology and do not transport HRP retrogradely. Maturation of this pool of incompletely differentiated neurons appears to be one mechanism whereby neuron number is augmented during postnatal life. (C) 2003 Elsevier B.V. All rights reserved.
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