期刊
NEUROSCIENCE LETTERS
卷 347, 期 1, 页码 17-20出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00635-9
关键词
Saitohin; tau haplotype; Alzheimer's disease; Parkinson's disease; Parkinson's disease with dementia; case-control study; multi-ethnic
资金
- NCRR NIH HHS [RR00645] Funding Source: Medline
- NIA NIH HHS [5 P50 AG08702-13, AG07232] Funding Source: Medline
- NINDS NIH HHS [NS36630] Funding Source: Medline
In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n = 344, P < 0.03; controls n = 458, P < 0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P = 0.2). (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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