期刊
JOURNAL OF CELL SCIENCE
卷 116, 期 16, 页码 3259-3267出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00667
关键词
mitochondria; protein import; translocator; TOM; TIM
类别
Nearly all mitochondrial proteins are synthesized in the cytosol and subsequently imported into mitochondria with the aid of translocators: the TOM complex in the outer membrane, and the TIM23 and TIM22 complexes in the inner membrane. The TOM complex and the TIM complexes cooperate to achieve efficient transport of proteins to the matrix or into the inner membrane and several components, including Tom22, Tim23, Tim50 and small Tim proteins, mediate functional coupling of the two translocator systems. The TOM complex can be disconnected from the TIM systems and their energy sources (ATP and DeltaPsi), however, using alternative mechanisms to achieve vectorial protein translocation across the outer membrane.
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