期刊
JOURNAL OF COGNITIVE NEUROSCIENCE
卷 15, 期 6, 页码 771-784出版社
MIT PRESS
DOI: 10.1162/089892903322370708
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资金
- NIMH NIH HHS [MH63901] Funding Source: Medline
- NINDS NIH HHS [NS40813] Funding Source: Medline
Interactions between prefrontal cortex (PFC) and stimulus-specific visual cortical association areas are hypothesized to mediate visual working memory in behaving monkeys. To clarify the roles for homologous regions in humans, event-related fMRI was used to assess neural activity in PFC and fusiform face area (FFA) of subjects performing a delay-recognition task for faces. In both PFC and FFA, activity increased parametrically with memory load during encoding and maintenance Of face Stimuli,, despite quantitative differences in the magnitude of activation. Moreover, timing differences in PFC and FFA activation during Memory encoding and retrieval implied a context dependence in the flow of neural information. These results support existing neurophysiological models of visual working memory developed in the nonhuman primate.
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