期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 66B, 期 2, 页码 559-566出版社
WILEY
DOI: 10.1002/jbm.b.10046
关键词
salting out; nanoparticles; poly(lactic-co-glycolic acid); drug delivery
In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect. (C) 2003 Wiley Periodicals, Inc.
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