期刊
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
卷 89, 期 9, 页码 1753-1758出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.apmr.2007.12.049
关键词
automobile driving; cognition; multiple sclerosis; muscle spasticity; neuropsychology; rehabilitation
资金
- University of California Center for Medicinal Cannabis Research [C00-SD-102, C00-SD-103]
- National Institute of Mental Health [R42 MH57593]
Objective: To examine the independent and combined impact of cognitive dysfunction and spasticity oil driving tasks involving high cognitive workload and lower-limb mobility in persons with multiple sclerosis (MS). Design: Single-visit cohort Study. Setting: Clinical research center. Participants: Participants included 17 drivers with MS and 14 referent controls. The group With MS exhibited a broad range of cognitive functioning and disability. Of the 17 patients with MS, 8 had significant spasticity in the knee used to manipulate the accelerator and brake pedals (based oil the Modified Ashworth Scale). Interventions: Not applicable. Main Outcome Measures: A brief neuropsychologic test battery and 2 driving Simulations. Simulation I required participants to maintain a constant speed and lane position while attending to a secondary task. Simulation 2 required participants to adjust their speed to accelerations and decelerations of a lead car in front of them. Results: Patients with MS showed greater Variability in lane position (effect size, g=1.30), greater difficulty in maintaining a constant speed (g=1.25), and less ability to respond to lead car speed changes (g=1.85) compared with controls. Within the MS group, in a multivariate model that included neuropsychologic and spasticity measures, cognitive, functioning was the strongest predictor of difficulty in maintaining lane position during the divided attention task and poor response time to lead car speed changes, whereas spasticity was associated with reductions in accuracy of tracking the lead car movements and speed maintenance. Conclusions: In this preliminary Study, cognitive and physical impairments associated with MS were related to deficits ill specific components of simulated driving. Assessment of these factors may help guide the clinician regarding the types of driving behaviors that would Put patients With MS at ail increased risk for an automobile crash.
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