期刊
BLOOD
卷 102, 期 4, 页码 1155-1159出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-01-0334
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- NHLBI NIH HHS [R01 HL070219] Funding Source: Medline
- NIDDK NIH HHS [R01 DK048549] Funding Source: Medline
Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces, in turn, structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past 3 decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies. (C) 2003 by The American Society of Hematology.
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