期刊
BRITISH JOURNAL OF CANCER
卷 89, 期 4, 页码 687-690出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6601164
关键词
suppressor genes; point mutations; prostate tumours
类别
A recent report suggests that the KLF6 gene encoding the Kruppel-like factor 6 protein is a frequently mutated, putative tumour suppressor gene in prostate cancer. The aims of the present study were to confirm these initial findings by determining the frequency of exon2 KLF6 mutations in a cohort of European prostate cancer patients, and to investigate whether there was evidence for mutational inactivation of both the KLF6 and TP53 tumour suppressor loci in some tumours. We examined 32 primary prostate tumours and three prostate tumour cell lines for mutations by PCR amplification and direct dideoxy sequencing (KLF6), and by oligonucleotide microarray (p53GeneChip(TM)) analysis and dideoxy sequencing (TP53). Whereas TP53 mutations typical of prostate cancer were found at a frequency consistent with the literature, no KLF6 mutations were found in any of the tumour samples nor in the three prostate cancer cell lines.
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