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卷 44, 期 34, 页码 6475-6478出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)01584-3
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Thymidine derivatives containing a 4'-C-vinyl group or a 5'-C-allyl group are synthesized and used as building blocks for three different dinucleotides. These are evaluated as substrates for ring-closing metathesis cyclisations, and a protected 5'-C-allylthymidine homo-dimer is found to be the most reactive. A protected precursor for a conformationally restricted cyclic dinucleotide with a four carbon 5'-C to 5'-C connection is hereby efficiently obtained, whereas a corresponding three carbon 4'-C to 5'-C connection is obtained in a lower yield. (C) 2003 Elsevier Ltd. All rights reserved.
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