期刊
MOLECULAR BRAIN RESEARCH
卷 116, 期 1-2, 页码 168-175出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(03)00260-2
关键词
epilepsy; GABA(A) receptor; P2X2 receptors; P2X4 receptors; gerbil; hippocampus
Fast responses to extracellular ATP are mediated by the activation of P2X receptors. Native and cloned P2X receptors are permeable to monovalent cations such as Na+ and K+ as well as divalent cations such as Ca2+. However, altered P2X receptor expression has not been definitively determined under pathological conditions, particularly in epilepsy. Here we show that, in the seizure-sensitive (SS) gerbil, hippocampus, a recognized genetic epilepsy model, the expressions of both P2X2 and P2X4 receptors are markedly decreased as compared with that in the seizure-resistant (SR) gerbil. These alterations are closely related to changes in gamma-aminobutyric acid (GABA) concentrations induced by vigabatrin (VGB) or 3-mercaptopropionic acid (3-MPA) treatment. Furthermore, the regulation of both P2X receptor expression in the gerbil hippocampus was mediated by the GABA(A) receptor, not GABA(B). These results suggest that the GABA(A) receptor-mediated modulation of P2X receptor expression may play an important role in the regulation of neuronal excitability. (C) 2003 Elsevier B.V. All rights reserved.
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