期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 38, 期 5, 页码 677-682出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0432-3
关键词
Piper bavinum; Piperaceae; AChE; BChE; Alzheimer's disease
资金
- National Foundation for Science and Technology Development, Vietnam [104.01-2010-16]
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [22A20130000073]
- National Research Foundation of Korea [22A20130000073] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 mu M. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 mu M.
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