期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 38, 期 5, 页码 659-665出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0407-4
关键词
Organoseleniums; Bis(aryl or aralkyl) diselenides; Diselenides; Antiproliferative activities; Human breast cancer
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [2012050022]
- National Research Foundation of Korea [2012R1A1A3014641] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A new series of bis(aryl or aralkyl) diselenides 5a-5q was synthesized by selenylation from aryl halide (or aralkyl halide) for development of new anticancer agents. The process involves the reaction of aryl halides (or aralkyl halides) with selenium, hydrazine hydrate under atmospheric pressure in the presence of sodium hydroxide, to afford diorganodiselenides. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 17 synthesized compounds for inhibiting the growth of these cell lines, 1,2-bis(chloropyridazinyl) diselenide 5a showed the highest potency. This result suggests the potential anticancer activity of compound 5a.
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