期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 37, 期 6, 页码 689-697出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-014-0385-6
关键词
Programmed necrosis; Necroptosis; Small molecules; Regulation; Signaling pathway
资金
- college of pharmacy-specialized research fund (the Institute for New Drug Development) of Keimyung University
Necroptosis is an active and well-orchestrated necrosis, distinctive from apoptosis in microscopic structure, and biochemical and molecular features. Unlike apoptosis-undergoing cells, which are removed by macrophage or neighboring cells, necrotic cell death releases danger signals and provokes inflammation, and further a severe damage to neighbor tissue. A regulated necrosis, termed as necroptosis or programmed necrosis, is emerging as a new paradigm of cell death that can be activated when apoptotic machinery is genetically or pathogenically defective. It plays biological significances in pathogenesis of a variety of inflammatory diseases as well as in a beneficial innate immune defense mechanism. This review highlights the identification of hits against necroptosis, and comprehensive approaches to discovery of small molecules that regulate necroptotic cell death. Also, the signaling molecular mechanism of necroptosis and future clinical uses of necroptosis inhibitor will be described in brief.
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