期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 37, 期 11, 页码 1437-1444出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0291-3
关键词
Aralia continentalis; Ultrasonic-assisted extraction; Optimization; Response surface methodology; Continentalic acid
资金
- 'Construction of the Basis for Practical Application of Herbal Resources' at the Korea Institute of Oriental Medicine - Ministry of Education, ICT & Future Planning of Korea [K13020]
In order to optimize the extraction conditions of continentalic acid, the main compound from Aralia continentalis root, we developed a model using the response surface methodology. The continentalic acid yield was analyzed and quantified by high-performance liquid chromatography coupled with UV detection. The extraction solvent, temperature, and time the three main factors for ultrasound-assisted extraction were optimized using the central composite design. Analysis of variance showed a good model fit (R-2 = 0.9323). The maximum extraction of continentalic acid obtained experimentally was 1.0138 % under an extraction temperature of 33 degrees C and extraction time of 28 min when 100 % ethanol was used as the solvent. The experimental value was in good agreement (the yield 1.0103 %) with those predicted values. The results clearly showed that quality by statistical design could be effectively applied to optimize extraction of continentalic acid.
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