期刊
THEORETICAL POPULATION BIOLOGY
卷 64, 期 2, 页码 141-150出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0040-5809(03)00071-6
关键词
identity-by-descent; isolated populations; junctions; population growth; population subdivision; linkage disequilibrium
资金
- NIGMS NIH HHS [GM-46255] Funding Source: Medline
Linkage disequilibrium (LD) reflects coinheritance of an ancestral segment by chromosomes in a population. To begin to understand the effects of population history on the extent of LD, we model the length of a tract of identity-by-descent (11313) between two chromosomes in a finite, random mating population. The variance of an 11313 tract is large: a model described by (Genet. Res. Cambridge 35 (1980) 13 1) underestimates this variance. Using Fisher's concept of junctions, we predict the mean length of an 11313 tract, given the age of the population and the population sizes over time. We derive results also for subdivided populations, given times of subdivision events and sizes of the resulting subpopulations. The model demonstrates that population growth and subdivision strongly affect the expected length of an IBD tract in small populations. These effects are less dramatic in large populations. (C) 2003 Elsevier Science (USA). All rights reserved.
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