期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 36, 期 5, 页码 517-535出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-013-0091-9
关键词
Tryptanthrin; Alkaloid; Indoloquinazolinone
资金
- Korean Science Foundation [KRF-2008-521-E00189]
Tryptanthrin, an indoloquinazoline alkaloid, was first obtained by sublimation of natural indigo and later isolated from the culture of fungus Candida lipolytica and a variety of other natural sources. Tryptanthrin showed a variety of intriguing biological properties such as antibacterial, antifungal, antiprotozoal, and antiparasitic activities, inhibitory activities against COX-2, 5-LOX, NO synthase and PGE(2) expression, as well as cytotoxic and antitumor activities. Present review covers recent studies on the natural sources, biological activities and mechanisms of their actions, synthesis, structure-activity relationship, and metabolism of tryptanthrin.
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