期刊
NEUROCHEMISTRY INTERNATIONAL
卷 43, 期 4-5, 页码 317-322出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0197-0186(03)00018-4
关键词
MRS; localization; in vivo; glycogen; NAA; brain
资金
- NCRR NIH HHS [P41RR08079] Funding Source: Medline
- NIDDK NIH HHS [R21DK58004] Funding Source: Medline
- NINDS NIH HHS [R01NS38672] Funding Source: Medline
Brain glycogen metabolism was recently observed in vivo and found to be very slow in the lightly alpha-chloralose anesthetized rat [J. Neurochem. 73 (1999) 1300]. Based on that slow turnover, the total glycogen content in the awake rat brain and its turnover time were assessed after administering C-13-labeled glucose for 48 h. Label incorporation into glycogen, glucose, amino acid, and N-acetyl-aspartate (NAA) resonances was observed. The amount of C-13 label incorporated into glycogen was variable and did not correlate with that in glutamate (r = -0.1, P > 0.86). However, the amount of C-13 label incorporated into glycogen was very similar to that in NAA (r = 0.93), implying similar turnover times between brain glycogen and NAA (similar to10h). Absolute quantification of the total concentration of brain glycogen in the awake, normoglycemic rat yielded 3.3 +/- 0.8 mumol/g (n = 6, mean +/- S.D.). (C) 2003 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据