期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 136, 期 6, 页码 1442-1453出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2015.10.009
关键词
Chronic rhinosinusitis; nasal polyps; mucociliary clearance; epithelial cells; inflammation; microbiome
资金
- USPHS grants [R01DC013588, R21DC013886, R03DC013862]
- National Institutes of Health [T32 AI083216, R01 AI104733]
- Ernest S. Bazley Foundation
- Chronic Rhinosinusitis Integrative Studies Program [U19-AI106683]
- RLG Foundation
There are a variety of medical conditions associated with chronic sinonasal inflammation, including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided into 2 major subgroups based on whether nasal polyps are present or absent. Unfortunately, clinical treatment strategies for patients with chronic sinonasal inflammation are limited, in part because the underlying mechanisms contributing to disease pathology are heterogeneous and not entirely known. It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal epithelial cell barrier, and tissue remodeling all contribute to the chronic inflammatory and tissue-deforming processes characteristic of CRS. Additionally, the host innate and adaptive immune responses are also significantly activated and might be involved in pathogenesis. Recent advancements in the understanding of CRS pathogenesis are highlighted in this review, with special focus placed on the roles of epithelial cells and the host immune response in patients with cystic fibrosis, CRS without nasal polyps, or CRS with nasal polyps.
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