期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 35, 期 12, 页码 2093-2104出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-1206-4
关键词
Xanthone; 1,2,3-Triazoles; Click chemistry; Antitumor activity
资金
- Science & Technology Commission of Shanghai Municipality [054319909, 08JC1405500]
- Shanghai Leading Academic Discipline ProJect [B906]
To explore the more active antitumor compounds, two series of new xanthones, containing 1,4-disubstituted-1,2,3-triazole moiety were designed and synthesized. Eaton's Reagent and click reaction were used in the synthesis. Most of the title compounds showed good inhibitory activity against the hepatoma carcinoma cell line (Bel-7402) and human cervical carcinoma cell line (HeLa) in vitro. Compounds 10a, 10e, 10f, 11r and 11t had potent activity with IC50 values, ranging from 2.2 +/- 0.17 to 7.1 +/- 0.27 aeM, which was equivalent to Doxorubicin.
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