期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 35, 期 10, 页码 1779-1784出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-012-1010-1
关键词
Ilex rotunda; Hemiterpenes; Caffeoylquinic acids; Anti-oxidative activity
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0022929]
- Research Institute for Biomedical and Pharmaceutical Sciences
- Health Care System, Chung-Ang University
- National Research Foundation of Korea [2010-0022929] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Chromatographic separation of the 80% MeOH extract of the leaves of Ilex rotunda (IR) led to isolation of two new hemiterpene glycosides, tentatively named as rotundarpenoside A (1) and rotundarpenoside B (2), along with five known caffeoyl derivatives (3-7). The chemical structures of these compounds were elucidated using 1D/2D NMR, HR-MS, and the absolute configuration was confirmed by Mosher's method. In order to evaluate their anti-oxidative activities, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT) were determined.
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