期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 34, 期 4, 页码 625-633出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-0413-8
关键词
Magnolol; Apoptosis; Lung carcinoma cells; Caspase-3; Nuclear factor-kappa B; Angiogenesis
资金
- Ministry of Education, Science and Technology [2005-0049404]
Lung malignancy is a major cause of human mortality. As such, safe pharmacological agents that can detect lung cancer are urgently required. Magnolol has been reported to have anticancer property. However, it is still unclear whether magnolol induces apoptosis of lung carcinoma cells. In this study, magnolol inhibited cell growth, increased lactate dehydrogenase release, and modulated cell cycle in human lung carcinoma A549 cells. Magnolol induced the activation of caspase-3 and cleavage of Poly-(ADP)-ribose polymerase, and decreased the expression level of nuclear factor-kappa B/Rel A in the nucleus. In addition, magnolol inhibited basic fibroblast growth factor-induced proliferation and capillary tube formation of human umbilical vein endothelial cells. These data indicate that magnolol is a potential candidate for treating of human lung carcinoma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据