期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 34, 期 10, 页码 1615-1621出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-1005-3
关键词
Isatin; Benzimidazole; Thiazoline; Breast cancer; Anticancer activity
A series of new isatin-thiazoline 3a-h and isatin-benzimidazole 4a-h derivatives were synthesized via condensation of isatin Mannich bases 2a-h with either 2-aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were characterized by spectral data. The anti-breast cancer activity of some of the synthesized compounds was assessed in the MCF-7 human breast cancer cell line. The results showed that compounds 4b, 4d and 4g possess significant antiproliferative activity against MCF-7 cells.
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