A β-Resorcylic Macrolide from the Seagrass-derived Fungus Fusarium sp PSU-ES73

A new beta-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known beta-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.