期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 34, 期 8, 页码 1373-1380出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-0818-4
关键词
Mori Cortex Radicis; Moraceae; 2-Arylbenzofurans; Oxygen-glucose deprivation; MTT; ROS
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0028078]
Three known 2-arylbenzofurans, moracin P (1), moracin 0 (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC50 values of 10.4, 12.6, and 15.9 mu M, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC50 values of 1.9, 0.3 and 12.1 mu M, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dose-dependent manner. Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.
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