期刊
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
卷 14, 期 5, 页码 790-796出版社
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532003000500014
关键词
antimicrobial activity; hydrazides; quinolones
Reaction of the quinolones 6-8 with hydrazine afforded the hydrazide 9-11 in moderate yields. Condensation of 9 and 11 with CS2/KOH furnished the potassium salts 13 and 14, respectively, which spontaneously afforded the 3-(1,2,4-triazolyl)-quinolones 15 and 16, respectively, on treatment with hydrazine. Reaction of 9 in refluxing CS2/KOH gave the 3-(1,2,4-oxadiazolyl)-quinolone 17. Alternatively, 15 was prepared from 17. The azide derivative 12, obtained from 10, furnished the alpha-amino ester derivative 18, on reaction with the glycine ethyl ester. Coupling of 10 with various sugars gave the N'-aldehydoglycosyl-quinolone-3-yl) carbohydrazides 19a-e. The newly synthesized compounds were screened for their antibacterial activity.
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