期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 34, 期 12, 页码 2003-2006出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-011-1221-x
关键词
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资金
- Stem Cell Research Center [SC-3240]
- National Research Foundation (Korea Ministry of Education, Science and Technology) [NRF-2010-0020405]
- Cell Bio RD funds
- National Research Foundation of Korea [2010-0020405, 12-2008-13-004-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Bone marrow is a reservoir for hematopoietic stem cells, endothelial precursor cells, and bone marrow stromal cells (also generally called mesenchymal stem cells), whose positive role in tissue repair is highly anticipated. In this report, we introduce a novel function of substance-P (SP), an 11-amino-acid peptide, as an injury-inducible messenger to mobilize bone marrow stem cells to the blood and finally to engage in tissue repair. This new drug may substitute for ex vivo cell culture of therapeutic cells by stimulating cell proliferation in the bone marrow in vivo and mobilizing those therapeutic cells to the patient's own blood stream. Again, the additional role of SP in mitigating inflammation-mediated tissue damage can further rationalize the clinical development of SP-peptide as a stem cell stimulant.
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