期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 33, 期 2, 页码 231-235出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-0207-4
关键词
Aspergillus versicolor; Cytotoxicity; Antibacterial activity; Polyketide; Xanthone; Anthraquinone
资金
- Ministry of Land, Transport, and Maritime Affairs, Korea
As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 mu g/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 mu g/mL.
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