期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 33, 期 6, 页码 875-880出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-0610-x
关键词
Platycodon grandiflorum; Campanulaceae; Advanced glycation end products (AGEs); Rat lens aldose reductase (RLAR); Diabetic complications
资金
- Korea Institute of Oriental Medicine [K09030]
- Korea Basic Science Institute (KBSI)
- National Research Council of Science & Technology (NST), Republic of Korea [K09030] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-beta-D-glucopyranoside (2), apigenin-7-O-(6 ''-O-acetyl)-beta-D-glucopyranoside (3), luteolin (4), litteolin-7-O-beta-D-glucopyranoside (5), luteolin-7-O-(6 ''-O-acetyl)-beta-D-glucopyranoside (6), isorhamnetin-3-O-neohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-beta-D-glucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), beta-sitosterol glucoside (14), and alpha-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.
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