期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 33, 期 3, 页码 375-380出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-010-0305-3
关键词
Nigrospora sp.; Cyclohexenes; Lactones; Cytotoxic activity; Antioxidant activity; Antibacterial activity
资金
- Commission on Higher Education
- Thailand Research Fund [RTA5180007]
- Center for Innovation in Chemistry (PERCH-CIC)
- Prince of Songkla University
Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (-)-drimenin (7) and diketopiperazine derivative (8), were obtained from the fungus Nigrospora sp. PSU-F12. Their structures were established by spectroscopic evidence. We also tested their cytotoxic (on African green monkey kidney fibroblast and breast cancer cells), antioxidant (in the DPPH assay), and antibacterial (against the standard Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus) activities.
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