Mechanical properties and biochemical activity of remineralizing resin-based Ca-PO4 cements

Objectives. This study examined strength and bioactive (remineralizing) properties of a powder/liquid formulation (Cement I) and a more practical two-paste formulation (Cement II) of a fluoride-releasing resin-based Ca-PO4 cement. Methods. For the remineralization potential, the dissolution of calcium, total ionic phosphate and fluoride from set cement specimens were determined in buffered saline and saliva-like solution (SLS). Artificial caries lesions were produced on coronal dentin of extracted human molars. On each tooth, two defined areas were coated, one with a composite resin (calcium-free control), the other with either Cement I or II After incubation in SLS, the mineral loss under the cement was analyzed by digitized microradiography and compared to that under the control. Results. The diametral tensile strength of Cement II of approximately 30 MPa after 24 h and 23 MPa after 4 weeks was 2 to 3 times higher than that of Cement I (ANOVA, t-test, p < 0.05). Calculations of the ion-activity products and Gibb's free energy from solution ion concentrations indicated a significant potential for the formation of fluor- and/or hydroxyapatite. Concurrently, both cements caused increases of 47% (Cement I) and 38% (Cement II) in the lesion mineral content over that underneath the corresponding controls. Significance. These in vitro results suggest that the stronger Cement H could serve as a restoration-supporting lining material and could remineralize dentin in areas where complete removal of carious tissue is contra-indicated. Published by Elsevier Science Ltd. on behalf of Academy of Dental Materials.