期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 31, 期 5, 页码 666-670出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-001-1210-9
关键词
Actinidia arguta; actinidiaceae; 3-O-trans-p-coumaroyl actinidic acid; triterpene; pancreatic lipase; obesity
A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC(50) of 14.95 mu M, followed by ursolic acid (2, IC(50) = 15.83 mu M). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC(50) values ranging from 20.42 to 76.45 mu M.
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