期刊
ARCHIVES OF PHARMACAL RESEARCH
卷 31, 期 8, 页码 965-969出版社
PHARMACEUTICAL SOC KOREA
DOI: 10.1007/s12272-001-1252-z
关键词
Atractylodes lancea; asteraceae; constituent; atractylenolide; dihydrobenzofuran; cytotoxicity
资金
- Commonweal Foundation of Jiangsu Province [M2004525]
A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraccae), along with ten known Compounds, including atractylencilide II (2), phi-taraxasteryl acetate (3), taraxerol acetate (4). beta-sitosterol (5), stigmasterol (6), beta-eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O-beta-D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and ail isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据