期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 13, 期 17, 页码 2907-2911出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(03)00588-2
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资金
- NIGMS NIH HHS [GM-57550, R01 GM057550] Funding Source: Medline
A series of greatly simplified microcystin analogues comprised only of Adda (the beta-amino acid common to the microcystins. nodularins, and motuporin,) and a single additional amino acid residue was synthesized and screened for inhibition of the protein phosphatases I and 2A. Several of the analogues were shown to be mid-nanomolar inhibitors of the enzymes. (C) 2003 Published by Elsevier Ltd.
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