期刊
THEORETICAL POPULATION BIOLOGY
卷 64, 期 2, 页码 241-251出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0040-5809(03)00075-3
关键词
age of a mutation; diffusion process; frequency spectrum; coalescent process; population genetics
General formulae are derived for the probability density and expected age of a mutation of frequency x in a population, and similarly for a mutation with b copies in a sample of n genes. A general formula is derived for the frequency spectrum of a mutation in a sample. Variable population size models are included. Results are derived in two frameworks: diffusion process models for the frequency of the mutation; and birth and death process models. The coalescent structure within the mutant gene group and the non-mutant group is considered. (C) 2003 Elsevier Inc. All rights reserved.
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