期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 90, 期 3, 页码 1438-1448出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.01082.2002
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资金
- NIMH NIH HHS [MH-59995] Funding Source: Medline
The effect of gamma-aminobutyric acid ( GABA) on neuronal firing rate in rat suprachiasmatic nucleus (SCN) slices was examined using continuous recording methods. GABA inhibited neuronal discharge during both the subjective day and the subjective night in a concentration-dependent manner characterized by two apparent affinity states. The GABA(A) receptor agonist muscimol caused potent inhibition regardless of circadian time; repeated applications of the agonist did not reverse the direction of effect. The GABA(A) receptor antagonists bicuculline and picrotoxin increased excitability when applied during either subjective day or subjective night. A significant increase in GABA(A) receptor - mediated inhibition, as well as endogenous GABAergic tone, was observed on the second day after slice preparation. The GABA(B) receptor agonist baclofen inhibited cell firing during subjective day and night, but the GABA(B) antagonist phaclofen had no significant effect. These data provide additional strong support for a predominantly inhibitory role of GABA in the rat SCN, regardless of the time of application in relation to the circadian rhythm, and demonstrate an important level of plasticity of this system in vitro.
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