期刊
JOURNAL OF MOLECULAR EVOLUTION
卷 57, 期 3, 页码 255-260出版社
SPRINGER-VERLAG
DOI: 10.1007/s00239-003-2473-y
关键词
protein structure; Bayesian phylogeny; beta-lactamases
The serine beta-lactamases present a special problem for phylogenetics because they have diverged so much that they fall into three classes that share no detectable sequence homology among themselves. Here we offer a solution to the problem in the form of two phylogenies that are based on a protein structure alignment. In the first, structural alignments were used as a guide for aligning amino acid sequences and in the second, the average root mean square distances between the alpha carbons of the proteins were used to create a pairwise distance matrix from which a neighbor-joining phylogeny was created. From those phylogenies, we show that the Class A and Class D beta-lactamases are sister taxa and that the divergence of the Class C beta-lactamases predated the divergence of the Class A and Class D beta-lactamases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据