期刊
JOURNAL OF PSYCHOPHARMACOLOGY
卷 17, 期 3, 页码 300-309出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/02698811030173012
关键词
acute tryptophan depletion; attention; CANTAB; learning; memory; mood; serotonin
Serotonin (5-HT, 5-hydroxytryptamine) may have. an important role in the maintenance of normal neuropsychological. functioning. The method of acute tryptophan depletion (ATD) provides a pharmacological challenge by which central 5-HT levels can be temporarily decreased and effects on learning, memory and mood examined. Twenty healthy male volunteers were recruited to take part in this within-subject, double-blind, crossover study. Neuropsychological function was evaluated 4-6 h after ingestion of,a control or 52 g tryptophan (TRP) depleting amino-acid drink. ATD significantly lowered levels, of plasma total and free TRP (p < 0.001), but this did not affect mood or performance on tests of verbal. and visuo-spatial learning and memory, attention or I executive function, These results contradict previous findings; however, the degree of disruption of central 5-HT levels resulting from the use of the 52 g amino-acid protocol may be an important factor in explaining the lack of effect. By utilizing more specific probes of individual 5-HT receptor subtypes, future studies can fully explore the role of 5-HT in neuropsychological functioning and. may elucidate the factors determining vulnerability to the effects of serotonergic dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据