期刊
JOURNAL OF CELL SCIENCE
卷 116, 期 17, 页码 3463-3470出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.00674
关键词
Sema4D/CD 100; Sema4A; CD72; Tim-2; plexin
类别
The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called 'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sema4A use CD72 and Tim-2, respectively, as receptors during immune responses; these receptors comprise a set distinct from those used by semaphorins in the nervous system. Sema4D/CD100, which is expressed constitutively by T cells, is involved in the activation of B cells and dendritic cells, whereas Sema4A is preferentially expressed on B cells and dendritic cells, and is involved in the activation of T cells. Additionally, increasing evidence suggests that some other semaphorins, including viral-encoded semaphorins, might also play important roles in the immune system.
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