期刊
ANNALS OF NEUROLOGY
卷 54, 期 3, 页码 379-382出版社
WILEY-LISS
DOI: 10.1002/ana.10671
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资金
- NIA NIH HHS [AG 13956, AG 05681] Funding Source: Medline
- NINDS NIH HHS [K08 NS 02190, NS 40525] Funding Source: Medline
We examined the potential role of the extra-cellular matrix-degrading enzyme, matrix metalloproteinase-9 (MMP-9), in the pathogenesis of cerebral amyloid angiopathy (CAA)-induced spontaneous hemorrhage. The amyloid-beta peptide (Abeta) induced the synthesis, release and activation of MMP-9 in murine cerebral endothelial cells, resulting in increased extracellular matrix degradation. Furthermore, extensive MMP-9 immunoreactivity was observed in CAA-vessels with evidence of microhemorrhage in aged APPsw transgenic mice, but not detected in aged wild type or young APPsw mice. These results suggest that increased vascular MMP-9 expression, stimulated by AP, may play a role in the pathogenesis of spontaneous intracerebral hemorrhage in patients with CAA.
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