期刊
OPTICS LETTERS
卷 28, 期 17, 页码 1546-1548出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.28.001546
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- NHLBI NIH HHS [HL25934] Funding Source: Medline
Contrast agents are utilized in virtually every imaging modality to enhance diagnostic capabilities. We introduce a novel class of optical contrast agent, namely, encapsulating microspheres, that are based not on fluorescence but on scattering nanoparticles within the shell or core. The agents are suitable for reflection- or scattering-based techniques such as optical coherence tomography, light microscopy, and reflectance confocal microscopy. We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse. (C) 2003 Optical Society of America.
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