期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 78, 期 3, 页码 370-375出版社
AMER SOC CLINICAL NUTRITION
DOI: 10.1093/ajcn/78.3.370
关键词
trans fatty acids; hydrogenated fat; LDL particle size; diet; cholesterol
资金
- NHLBI NIH HHS [HL 54727] Funding Source: Medline
Background: Dietary trans fatty acids (FAs), which are formed during the process of hydrogenating vegetable oil, are known to increase plasma LDL-cholesterol concentrations. However, their effect on LDL particle size has yet to be investigated. Objective: We investigated the effect of trans FA consumption on the electrophoretic characteristics of LDL particles. Design: Eighteen women and 18 men each consumed 5 experimental diets in random order for 35-d periods. Fat represented 30% of total energy intake in each diet, with two-thirds of the fat in the form of semiliquid margarine (0.6 g trans FAs/100 g fat), soft margarine (9.4 g trans FAs/100 g fat), shortening (13.6 g trans FAs/100 g fat), stick margarine (26.1 g trans FAs/100 g fat), or butter, which was low in trans FAs (16 g trans FAs/100 g fat) but rich in saturated fat. LDL particle size and distribution were characterized by nondenaturing, 2-16% polyacrylamide gradient gel electrophoresis. Results: Relative to the LDL particle size observed after consumption of the butter-enriched diet, LDL particle size decreased significantly and in a dose-dependent fashion with increasing amounts of dietary trans FAs (P < 0.001). Cholesterol concentrations in large (> 260 Angstrom) and medium-sized (255-260 Angstrom) LDL particles also increased proportionately to the amount of trans FAs in the diet. Conclusion: Consumption of dietary trans FAs is associated with a deleterious increase in small, dense LDL, which further reinforces the importance of promoting diets low in trans FAs to favorably affect the lipoprotein profile.
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