期刊
JOURNAL OF CELL SCIENCE
卷 116, 期 17, 页码 3471-3478出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.00703
关键词
chemotaxis; Dictyostelium; PI 3-kinase; fibroblasts; neutrophils; actin
类别
Chemoattractant-responsive cells are able to translate a shallow extracellular chemical gradient into a steep intracellular gradient resulting in the localization of F-actin assembly at the front and an actomyosin network at the rear that moves the cell forward. Recent evidence suggests that one of the first asymmetric cellular responses is the localized accumulation of PtdIns(3,4,5)P-3, the product of class I phosphoinositide 3-kinase (PI3K) at the site of the new leading edge. The strong accumulation of PtdIns(3,4,5)P-3 results from the localized activation of PI3K and also from feedback loops that amplify PtdIns(3,4,5)P-3 synthesis at the front and control its degradation at the side and back of cells. These different pathways are temporally and spatially regulated and integrate with other signaling pathways during directional sensing and chemotaxis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据