期刊
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
卷 178, 期 9, 页码 2003-2017出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10426500390228693
关键词
17-thioxoandrosten-3-one; antibacterial; antifungal; Lawesson's reagent; mercaptooxathiaphospholoandrosten-2-thione; steroids; thiazaphosphorinothieno steroids
The reactivity of Lawesson's reagent (LR) toward some steroidal hormones was studied, 4-androsten-3,17-dione 2 reacted with LR to produce the corresponding thioxosteroids 3 and 4. Epi-androsterone 5 showed a great activity to LR and produced 3,6-mercaptospiro(androstan-17,4'dithiaphosphetan)thione 8 and the sulfide derivative 9. Also progesterone 10 reacted with LR to yield the thiaphospholo[3', 4':16,17]androsten-3-one 13 and the sulfide product 16. The new modified steroidal derivatives thieno[2',3:2,3]cholestan 18 and thieno[2',3':2,31-androstan 20 were synthesized and examined against LR, the corresponding thiazaphosphorinothieno steroidal derivatives 23 and 24 were isolated respectively. The in vitro biological activity of some newly synthesized compounds against bacteria, yeast, and fungi was studied.
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