期刊
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
卷 33, 期 9, 页码 758-761出版社
WILEY
DOI: 10.1046/j.1365-2362.2003.01192.x
关键词
coagulation; endotoxin; inflammation; thrombin
Background Bacterial endotoxins can induce the synthesis and release of vascular endothelial growth factor ( VEGF), which may alter vascular permeability and cause vascular leakage. Materials and methods The effect of acute systemic inflammation on VEGF concentration was measured in healthy males after an intravenous bolus infusion of Escherichia coli endotoxin ( lipopolysaccharide, LPS, 20 IU kg(-1)) in a double-blind, placebo-controlled parallel group study. LPS administration was followed by an infusion of lepirudin ( bolus 0.1 mg kg(-1), continuous infusion of 0.1 mg kg(-1) h(-1), n = 12) or saline (n = 12). Results Plasma VEGF increased from a mean of 15.1 pg mL(-1) to 74.6 pg mL(-1) 5 h after LPS (P < 0.003). Body temperature, pulse rate, leukcytes, prothrombin fragment 1 + 2 (F 1 + 2) and lactoferrin increased and platelets decreased after LPS ( P < 0.05). The LPS-induced increase in VEGF was paralleled by the neutrophil cell degranulation marker lactoferrin but not by F 1 + 2, and was not affected by lepirudin, which blunted F 1 + 2 formation ( P < 0.05). Conclusions Inflammation-induced activation of leukcytes rather than platelets plays a role in the marked increase in VEGF, which cannot be abrogated by antithrombotic therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据