期刊
INTERNATIONAL IMMUNOLOGY
卷 15, 期 9, 页码 1053-1061出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxg104
关键词
dendritic cell; fever; hsp90
类别
Fever is a phylogenetically conserved biological phenomenon and a common consequence of infection. Here, we examine in vitro and in vivo the effect of febrile temperature on dendritic cells (DC), a key antigen-presenting cell in the immune system. Elevated temperatures are observed to cause immature DC to mature, specifically through elevation of intracellular levels of hsp90. Surprisingly, even brief exposure to elevated temperatures has a powerful effect on the immunostimulatory capacity of DC. These results bear on the mechanisms of the salutary effects of fever as well as of behavioral elevations of temperature such as saunas and warm blankets.
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