期刊
JOURNAL OF CLINICAL NEUROSCIENCE
卷 10, 期 5, 页码 584-588出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0967-5868(03)00192-9
关键词
Parkinson's disease; freezing of gait; akinesia; paroxysmal gait disorders
资金
- NIA NIH HHS [AG-08812, AG-141 00] Funding Source: Medline
- NICHD NIH HHS [HD-39838] Funding Source: Medline
- PHS HHS [R-R-13622] Funding Source: Medline
Background: The pathophysiology of freezing of gait (FOG) is unclear. Objective: To assess the relationships between FOG and other parkinsonian features in Parkinson's disease (PD), focusing on levodopa effects. Methods: Nineteen PD patients with significant FOG in off were assessed while off and on. Three observers independently viewed videotapes of a 130-m walk and scored FOG frequency. The Unified Parkinson's disease Rating Scale was used to evaluate clinical state. Results: FOG frequency was not correlated with other parkinsonian features in off and only with speech and writing in on. Levodopa significantly decreased FOG frequency (p < 0.001). This reduction was strongly correlated with improvement of tremor (R = 0.80, p < 0.01) and speech (R = 0.62, p < 0.05), but not with improvement in rigidity, bradykinesia, or balance. Conclusion: Levodopa decreases FOG in PD. FOG is apparently an independent motor symptom, caused by a paroxysmal pathology that is different from that responsible for bradykinesia, rigidity or postural instability. (C) 2003 Elsevier Science Ltd. All rights reserved.
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