期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 14, 期 3, 页码 99-108出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1382-6689(03)00044-9
关键词
bisphenol A; development; spontaneous activity; active avoidance test; open-field behavior; rat
The objective of this investigation is to evaluate whether perinatal maternal exposure to bisphenol A (BPA) at 4, 40, and 400 mg/kg per day affects the behavior of offspring in F344 rats. Perinatal BPA exposure inhibited the body weight increases of male and female offspring in a dose-dependent manner, which continued after weaning. Spontaneous activity analyses revealed that BPA elongated immobile time during the dark phase in female offspring. At 4 weeks of age, male offspring exposed to BPA at 40 and 400 mg/ka per day performed avoidance responses significantly higher in the shuttlebox avoidance test. At 8 weeks of age, however, male offspring only at 4 mg/kg per day showed significantly lower responses. In the open-field behavior test at 8 weeks of age, male offspring exposed to BPA only at 4 mg/kg per day showed a higher percent of grooming than the control male offspring. In conclusion, perinatal exposure to BPA caused the behavioral alterations in the offspring. (C) 2003 Elsevier B.V. All rights reserved.
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