期刊
MICROBES AND INFECTION
卷 5, 期 11, 页码 947-950出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(03)00180-1
关键词
feline leukemia virus; host range; infection; pseudotype assay; receptor
We reevaluated the host ranges of feline leukemia virus (FeLV) subgroups A, B and C using pseudotype assays based on recombinant NB-tropic murine leukemia Virus, which is not usually blocked after viral entry in mammalian cells. Pseudotype viruses of FeLV-B and -C infected a variety of cell lines from many mammalian species. Unexpectedly, FeLV-A pseudotype viruses of two independent isolates from the UK and US also infected a variety of non-feline cell lines including cells from humans, rabbits, pigs and minks. Moreover, both isolates of FeLV-A productively infected human embryonic kidney 293 and mink Mv-1-Lu cells. We conclude that FeLV-A is not strictly ecotropic. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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