期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 551, 期 2, 页码 601-608出版社
WILEY
DOI: 10.1113/jphysiol.2003.046029
关键词
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资金
- NHLBI NIH HHS [HL-045547, R01 HL045547] Funding Source: Medline
This investigation examined the interaction between carotid baroreflex (CBR) responsiveness during head-up tilt (HUT)-induced central hypovolaemia and aerobic fitness. Seven average fit (AF) individuals, with a mean maximal oxygen uptake (V-O2max) of 49 +/- 1 (ml O-2) kg-(1) min-(1), and seven high fit (HF) individuals, with a VO2max of 61 +/- 1 (ml O-2) kg-(1) min(-1), voluntarily participated in the investigation. After 10-15 min supine, each subject was exposed to nine levels of progressively increasing HUT by 10 deg increments from -20 deg to +60 deg. During the final 3 min of each stage of HUT, the CBR responsiveness was measured using a rapid pulse (500 ms) train of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr. The maximal gain of the carotid-HR (G(max)-HR) and carotid-MAP (G(max)-MAP) baroreflex function curves was identified as measures of CBR responsiveness. During HUT-induced decreases in thoracic admittance, an index of central blood volume (CBV), the G(max)-HR and G(max)-MAP of the AF subjects increased more than the G(max)-HR and G(max)-MAP of the HF subjects (P < 0.05). The data demonstrate that the increase in the CBR responsiveness during a tilt-induced progressive unloading of the cardiopulmonary baroreceptors was attenuated in endurance-trained subjects. These findings provide an explanation for the predisposition to orthostatic hypotension and intolerance in well-trained athletes.
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