Critical guidelines for validation of the selectivity of in-vivo chemical microsensors

Microsensors are miniaturized analytical devices for making in-situ chemical measurements in biological systems with extraordinary temporal resolution. Their most severe limitation is chemical selectivity. Here, we suggest guidelines that can be applied to a range of in-vivo microsensor applications for evaluation of analyte identification and improvement of selectivity. (C) 2003 Published by Elsevier B.V.